The keywords of the blue cluster were trimethylamine n-oxide, metabolism, phosphatidylcholine, stroke, red meat, etc. The keywords of the yellow cluster were gut microbiota, cardiovascular risk-factors, acute myocardial infarction, biomarker, nutrition, etc. The keywords of the purple cluster were atherosclerosis, endothelial dysfunction, c-reactive protein, mediterranean diet, low density lipoprotein, etc. The keywords of the dark blue cluster were myocardial infarction, bile acids, blood pressure, chain fatty acids, etc. The gene discussed is CRP; the disease is atherosclerosis.