In this study, we investigated the expression of adiponectin, visfatin, leptin, resistin, and novel adipokines chemerin and vaspin in the whole aortas isolated from mice with or without atherosclerosis and mice with relieved atherosclerosis after taking angiotensin-converting enzyme inhibitor (ACEI) to prevent atherosclerosis development using bioinformatic methods. Here, LEP is linked to atherosclerosis.