Univariate and multivariate analysis shows the high chemerin level was an independent predictor of CAD (β = 2.702, 95% CI, 1.344–5.431, P = 0.001) after adjusting for age, sex, diabetes, hypertension, hyperlipidemia, obesity, and smoking. Here, RARRES2 is linked to obesity due to melanocortin 4 receptor deficiency.