According to the multivariable logistic regression analysis, the development of MACE was associated with the complication of left heart disease (OR = 4.365, CI:1.306–14.591), and elevated NT-proBNP level (OR = 1.051, CI:1.015–1.088) and sPAP level estimated by echocardiography (OR = 1.021; CI: 1.003–1.040). This evidence concerns the gene PDZK1IP1 and heart disorder.