TRIB3 and atherosclerosis: We cannot completely rule out a contribution of TRIB3 to VSMC phenotypes in atherosclerosis; future use of conditional Trib3-knockout mouse strains for myeloid and VSMC specific expression, will help us understand these specific cellular contributions to by Trib3 to plaque stability, VMSC phenotype and the type of collagen production, beyond the scope of this current study.