Since the G allele of rs10757278 may regulate the expression of CDKN2A/2B (55, 56) and/or ANRIL (60, 61) and was closely related to the onset of myocardial infarction (3), it was reasonable to speculate that the G allele of rs10757278 very likely impacted lipid metabolism. This evidence concerns the gene CDKN2A and myocardial infarction.