Our study introduces the new gene RGPD4 as a candidate contributing to SSc-ILD upon evaluating SSc patients with and without an ILD phenotype with WES, and five of 80 patients were identified with deleterious or LoF variants of RGPD4. Patients carrying those variants showed predominance of lower levels of testosterone than those without variants. This evidence concerns the gene RGPD4 and systemic sclerosis.