While the allele frequency of RGPD4 did not reach significant difference between the SSc-ILD group (8.0%) and the SSc without ILD group (3.3%) (P = 0.645), its highest ranking encouraged us to assess the corresponding phenotypes of carriers and additional datasets to determine its correlation with the development of SSc-ILD (Table 4). The gene discussed is RGPD4; the disease is interstitial lung disease.