IL6 and malignant colon neoplasm: These processes include promoting cell proliferation (by regulating cyclin D, c-Myc, and IL-6, which regulate growth-promoting signals), inhibiting apoptosis (by inhibiting apoptotic genes including Bcl-2 and BclxL transcription), promoting angiogenesis (inducing VEGF expression), promoting tumor invasion (through E-selectin and MMPs), promoting generation of the epithelial mesenchymal transition (EMT) and colon cancer stem cells (CSCs), and mediating tumor drug resistance.