STAT3 and neoplasm: Moreover, the combination of CCM and EGCG not only attenuates the transition from normal endothelial cells to tumor endothelial cells induced by tumor conditioning medium by inhibiting the JAK/STAT3 signaling pathway, but also significantly reduces tumor growth and angiogenesis in a PDX mouse model of CRC; in this study, the combined anti-angiogenic effect was superior to that of CCM or EGCG alone (148).