PIK3CA and colorectal carcinoma: FraC (RGD-peptide fragacea toxin C) contained in strawberry anemone is significantly toxic to HCT-116 cells harboring the Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA)/Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation, but less toxic to normal cells, which may suggest a new CRC treatment option based on FraC-peptide (103).