Here, we found that POGLUT2 was mainly expressed in stromal cells, which is verified by StromalScore, ESTIMATEScore, ImmuneScore, and Tumor purity, and POGLUT2 was positively correlated with cancer-associated fibroblasts, macrophages, monocytes, and neutrophils in the tumor microenvironment. Here, POGLUT2 is linked to neoplasm.