Overexpression of mesenchymal markers is mediated by upregulation of SNAI1, one of the other miR-153 target genes in various types of cancer cells such as melanoma, esophageal squamous cell carcinoma, oral cancer, osteosarcoma, human epithelial cancer, pancreatic adenocarcinoma and laryngeal squamous cell carcinoma (48, 50, 54, 56, 57, 77). The gene discussed is SNAI1; the disease is melanoma.