In renal cell carcinoma, the signaling pathway involved in oncogenic effect of miR-153 is mainly PI3K/AKT signaling pathway which has a critical role in cell cycle progression and proliferation by upregulation of cyclin D1 as well as EMT-mediated metastasis by downregulation of E-cadherin and upregulation of Snai1. This evidence concerns the gene AKT1 and hereditary clear cell renal cell carcinoma.