In addition, the expression of RhoGTPase activating protein 18 (ARHGAP18), Rab-like protein 3 (Rabl3) and Rho associated coiled-coil containing protein kinase 1 (ROCK1), which play a vital role in migration and metastasis of cancer cells, are negatively regulated by miR-153 in hepatocellular carcinoma and breast cancer (51–53). Here, ARHGAP18 is linked to hepatocellular carcinoma.