Multivariate analysis demonstrated that poor differentiation, LVI, depth of tumor invasion, T1 substage, high-density lipoprotein cholesterol (HDL-C) level, and preoperative alanine aminotransferase/aspartate aminotransferase ratio (LSR) were significant independent risk factors for LNM (11, 14, 35, 37–39). The gene discussed is GPT; the disease is neoplasm.