Studies also found that these tumor cell lines can autocrine HSP90α to promote tumor migration, invasion and metastasis, including SH-76 hybridoma cells, HT-1080 fibro sarcoma cells, MDA-MB-231 breast cancer cells, MCF-7 breast cancer cells, HCT-8 colorectal cancer cells, Bladder cancer cells, B16 melanoma cells, PC3 prostate cancer cells, CaoV-3 ovarian cancer cells and HepG2 liver cancer cells (40, 41). The gene discussed is HSP90AA1; the disease is Familial prostate cancer.