EGFR and cancer: The nanopore-forming immunotoxin consisted of three distinct domains: a folate or nanobody [7d12 anti-epidermal growth factor receptor (EGFR) nanobody], a nanopore toxin-based moiety derived from Salmonella typhi [cytolysin A (ClyA)], and a protease domain (responsible for targeting cancer cells, reducing off-target toxicity against normal cells).