GH1 and neoplasm: This could be due to the PitNET and treatment affected body tissue adaptation to the SSA treatment, but further studies are needed to confirm this hypothesis. Previous studies have shown that these four miRNAs are downregulated in GH secreting PitNETs compared to normal pituitaries (14, 16, 25) suggesting that they may have tumor suppressive role in GH secreting PitNETs.