We evaluated the diagnostic power of the significant factors (Milan criteria, Metroticket_AFP, AFP model, presence of microvascular invasion, Edmondson–Steiner grade, log AFP value at the time of LT, and endothelial angiopoietin-2 expression in the explanted liver) by receiver operating characteristic (ROC) curve analysis to predict HCC recurrence after LT. The gene discussed is ANGPT2; the disease is hepatocellular carcinoma.