Among the best known, also externally validated, were the San Francisco criteria (single nodule ≤6.5 cm or two to three nodules ≤4.5 cm with a total diameter ≤8 cm) (8), the Up-To-Seven criteria [HCC which has 7 as the sum of the diameter (cm) of the major nodule and the number of nodules] (9), and the French-AFP model (point system based on tumor diameter, number of nodules, and AFP value) (10). This evidence concerns the gene AFP and hepatocellular carcinoma.