Previous transcriptome studies of IGCTs have shown that germinoma is characterized by the expression of genes involved in self-renewal (such as OCT4, NANOG, and KLF4) and immune response, while NGGCTs are characterized by the expression of genes involved in neuronal differentiation, WNT/β-catenin pathway, invasion, and epithelial-mesenchymal transformation (including SNAI2 (SLUG) and TWIST2) (36). Here, SNAI2 is linked to germinoma.