Once knockdown of GFPT1 or abrogation of its activity by a glutamine analog (6-diazo-5-oxo-l-norleucine, DON) in PDAC cells, these cells in co-cultured with cancer-associated fibroblasts reduced the secretion of tumor-promoting chemokine IL-27, as well as the production of hyaluronan, whose synthesis needs UDP-GlcNAc as one of the primary substrates (Sharma et al., 2020). The gene discussed is GFPT1; the disease is cancer.