Although AP5 has not been investigated in the context of viral infection, AP2, another type of AP complex has been shown to function as a target of ocular infection upon human adenovirus species D type 37 (HAdV-D37) infection (Lee et al., 2020) or be involved in the entry process of human enterovirus 71 (HEV71) (Hussain et al., 2011). The gene discussed is AP5B1; the disease is eye infection.