Although AP5 has not been investigated in the context of viral infection, AP2, another type of AP complex has been shown to function as a target of ocular infection upon human adenovirus species D type 37 (HAdV-D37) infection (Lee et al., 2020) or be involved in the entry process of human enterovirus 71 (HEV71) (Hussain et al., 2011). This evidence concerns the gene AP5B1 and viral infectious disease.