Alzheimer’s disease (AD) is the most common form of dementia, which was pathologically characterized by extracellular senile plaque (SP) formed by the deposition of β-amyloid (Aβ), and intracellular neurofibrillary tangles (NFTs) formed by the abnormally phosphorylated Tau protein aggregation as well as vascular amyloidosis and loss of neurons in the cortex and hippocampus (Edler et al., 2017; Szaruga et al., 2017). Here, MAPT is linked to Alzheimer disease.