Bacterial LPS or AlCl3 can cause AD-like pathology, aggravating neuroinflammation, oxidative stress, and acetylcholinesterase (AChE) activity in the brain of rodents (Tyagi et al., 2010; Mathiyazahan et al., 2015; Ahmad Rather et al., 2019; Huat et al., 2019). The gene discussed is ACHE; the disease is Alzheimer disease.