Consistent with previous studies in post mortem human AD brain samples (Schipper et al., 1995; Raina et al., 1999; Wang et al., 2000), we found that protein levels of NQO1 and HO-1 were significantly increased in the hippocampi of the APP mice compared to the WT group (Figures 1G,H). This evidence concerns the gene HMOX1 and Alzheimer disease.