HMOX1 and Alzheimer disease: Interestingly, in AD nuclear NRF2 levels are decreased compared to age-matched controls (Ramsey et al., 2007), but NQO1 and HO-1 are significantly overexpressed in the hippocampi of post mortem AD brains (Schipper et al., 1995; Raina et al., 1999; Wang et al., 2000).