In the current study, we show that eEF2K knockout alleviates the AD-associated overexpression of NQO1 and HO-1 in AD model mice (Figures 1G,H), suggesting the beneficial effects observed in the double mutant mice may be attributed to restored homeostasis of the NRF2-mediated antioxidant response. The gene discussed is EEF2K; the disease is Alzheimer disease.