EEF2K and Alzheimer disease: Notably, levels of NQO1 and HO-1 expression in hippocampi of the APP/eEF2K-/- mice were similar to those in the WT mice (Figures 1G,H), suggesting the genetic suppression of eEF2 phosphorylation ameliorated AD-related dysregulation of the NRF2-mediated antioxidant response.