Previous literature has reported significantly elevated protein levels of NQO1 and HO-1 in the brains of AD human patients compared to age-matched controls, suggesting a dysregulation of this NRF2-mediated antioxidant response (Schipper et al., 1995; Raina et al., 1999; Wang et al., 2000). The gene discussed is NQO1; the disease is Alzheimer disease.