MAPT and supranuclear palsy, progressive, 1: As the frontal lobes are the main cortical locus of neurodegeneration in PSP (Williams et al., 2007; Dickson et al., 2010), the dysfunction of the opercular-aslant-BA6 complex is not surprising, and probably has a multifactorial origin: tau deposits, neuronal and axonal loss, and also glial pathology are all typical findings in PSP brains (Zhukareva et al., 2006; Williams et al., 2007; Dickson et al., 2010).