These antioxidants play central neuro-protective roles in AD (Maines, 2000; Pini et al., 2016) Gene expression of Mn–, Cu-, and Zn-superoxide dismutase (Mn– and Cu, Zn-SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and glutathione reductase (GSSG-R) is enhanced (Aksenov et al., 1998). Here, CAT is linked to Alzheimer disease.