One of the earliest and most widely recognized of those published, the Hans algorithm, divides cases of DLBCL into germinal center lymphomas and non-germinal center lymphomas (further divided into activated B-cell lymphoma and lymphoma with type III gene expression) based on the expression of CD10, BCL-6, and MUM1 [10]. The gene discussed is MME; the disease is B-cell non-Hodgkin lymphoma.