CS: Cushing syndrome; DM: diabetes mellitus; GR: glucocorticoid receptor; TNBC: triple-negative breast cancer; GBM: glioblastoma multiforme; IOP: intraocular pressure; HPA: hypothalamic-pituitary-adrenal; GABA: gamma-aminobutyric acid; AD: Alzheimer’s disease. The gene discussed is NR3C1; the disease is Cowden syndrome 1.