CHCHD2 and Alzheimer disease: Immunohistochemical analysis revealed that CHCHD2 and CHCHD10 are abundantly expressed in nigrostriatal dopaminergic neurons, cortical and hippocampal pyramidal neurons, and motor neurons in the anterior horn of the spinal cord, which are associated with the pathology of PD, AD, and ALS-FTD (Burstein et al., 2018; Huang et al., 2018).