CHCHD10 and amyotrophic lateral sclerosis: CHCHD10 R15L transgenic mice, which had a shorter lifespan and degeneration of the central nervous system, skeletal muscle, and myocardium, did not have TDP-43-immunopositive inclusions, which was consistent with the pathological findings of the above patient with ALS (Keith et al., 2020; Ryan et al., 2021).