Coiled-coil-helix-coiled-coil-helix domain containing 10 (CHCHD10) (MIM#615903) has been identified as a causative gene in a large French family with autosomal dominant inheritance for patients with heterogeneous symptoms, including motor neuron disease, cerebellar syndrome, and cognitive decline (Bannwarth et al., 2014). This evidence concerns the gene CHCHD10 and motor neuron disorder.