GLS and neoplasm: The glutaminase (referred to as GLS hereafter) product is responsible for participating in the cellular tricarboxylic acid (TCA) cycle along with glutamine-derived a-ketoglutarate, thereby supporting cellular energy production and meeting biosynthetic requirements, thus promoting tumour cell growth and progression (Mafra and Dias, 2019) (Cluntun et al., 2017).