Using a cox prognostic model established by univariate cox analysis, multi-factor cox analysis, and lasso regression, based on the prognostic model with principal component analysis, we discovered that cuproptosis lncRNAs such as DARS-AS1, UBE1D3-AS1, and LYRM4-AS1 in glioma were significant high-risk lncRNAs; we used this finding to group patients into high- and low-risk groups. This evidence concerns the gene LYRM4 and glioma.