GLS and neoplasm: The dependence on glutamine has long been recognised as a hallmark of cancer cell metabolism and plays an important role in tumour development (Binkley et al., 2020) (Schultze and Aschenbrenner, 2021), during which GLS is frequently overexpressed in many malignancies and acts as an oncogene to support cancer growth (Gao et al., 2009) (Wang et al., 2010).