STAT1 binding on the homozygous CAD risk allele was reduced in lymphoblastoid cells (LCL) therefore, the knockdown of STAT1 in LCLs that were homozygous for the non-risk CAD allele upregulated CDKN2BAS suggesting a repressive role of STAT1 on CDKN2BAS expression. The gene discussed is CDKN2B-AS1; the disease is coronary artery disorder.