Haematopoietically expressed homeobox gene (Hhex) is vital in maintaining acute myeloid leukemia (AML), as its deletion causes upregulation of INK4a and ARF. Further, Hhex, like HLX1 and HOXA9, facilitates PRC2 binding to the promoters by interacting with the Suz12 subunit, thereby repressing the genes (Shields et al., 2016). Here, CDKN2A is linked to acute myeloid leukemia.