Silencing MICU1 increases mitochondrial Ca2+transfer, oxygen consumption by the stimulation of pyruvate dehydrogenase (PDH), which by converting pyruvate to acetyl CoA catalyzes the rate-limiting step of the metabolic fate between glycolysis versus OXPHOS, and results in the inhibition of ovarian cancer growth in vivo (Chakraborty et al., 2017). This evidence concerns the gene MICU1 and ovarian carcinoma.