Disrupting the interaction of Bcl-2 and IP3R3 through a BH4-domain targeting peptide, BIRD2, induces Bax/Bak dependent apoptosis in diffuse large B-cell lymphoma (DLBCL) and chronic lymphocytic leukemia (CLL) cells, through mitochondria Ca2+overload driving mitochondrial transition pore opening (mPTP) (Kerkhofs et al., 2021). Here, ITPR3 is linked to diffuse large B-cell lymphoma.