Interestingly, a selective peptide capable to delocalize the mitochondrial outer membrane bound glycolytic enzyme HK2 from EMCS, results in IP3R3-mediated mitochondrial Ca2+overload, killing of patient derived chronic lymphocytic leukemia B cells and reduced cancer growth in mice, without affecting healthy tissues (Ciscato et al., 2020). Here, ITPR3 is linked to B-cell chronic lymphocytic leukemia.