Different key tumor suppressors such as p53, the phosphatase tensin homolog (PTEN), promyelocytic leukemia (PML) protein, proto-oncogenes such as the serine/threonine kinase Akt kinase, breast/ovarian cancer susceptibility gene 1 (BRCA1), and various members of the B-cell lymphoma 2 (Bcl-2) family including B-cell lymphoma 2 (Bcl-2), B-cell lymphoma-extra large (Bcl-XL) and BCL-2 ovarian killer (BOK), have been found to localize to ECMS (Thomenius and Distelhorst, 2003; Monaco et al., 2015; Lalier et al., 2021). Here, PTEN is linked to neoplasm.