The mechanistic target of Rapamycin complex 2 (mTORC2)-Akt axis controls the phosphorylation-mediated inhibition of IP3R, which by preventing the transfer of Ca2+ from the ER to the mitochondria attenuates mitochondrial apoptosis, while it favors cancer cell’s aerobic glycolysis (Warburg effect) by phosphorylating hexokinase 2 (HK2), recently found as an essential component of EMCS in cancer cells (Betz et al., 2013; Ciscato et al., 2020). Here, ITPR1 is linked to cancer.