Importantly, previous transcriptomic analysis also highlighted an enrichment for altered mitochondrial pathways in the same dataset (Heher et al., 2022) and in FSHD muscle cells (Banerji et al., 2019), further arguing for a DUX4/β-CATENIN/mitochondrial functional network operating in FSHD pathogenesis. Here, DUX4 is linked to facioscapulohumeral muscular dystrophy.