In line, our GO analysis shows the biological process ‘Immune response’ as significantly enriched in the subset of genes up-regulated by DUX4 and down-regulated by DUX4c, suggesting that DUX4/DUX4c antagonism may take place in FSHD lymphoblasts in parallel to that we report in FSHD muscles/myoblasts. This evidence concerns the gene DUX4L9 and facioscapulohumeral muscular dystrophy.