Intriguingly, the expression profile of the 88 genes efficiently clustered FSHD samples separately from healthy controls upon hierarchical clustering analysis (Figure 3E; Supplementary Table S3), strengthening the hypothesis that DUX4/DUX4c antagonism may contribute to FSHD pathomechanisms. The gene discussed is DUX4L9; the disease is facioscapulohumeral muscular dystrophy.