DUX4 regulates many target genes and amongst the myriad of signalling pathways affected by DUX4 and dysregulated in FSHD, is the WNT/β-CATENIN interactome, nodal to vertebrate myoblast proliferation and differentiation (Schmidt et al., 2000; Fitzsimons, 2011; Banerji et al., 2015; Rudnicki and Williams, 2015; Suzuki et al., 2015). The gene discussed is DUX4; the disease is facioscapulohumeral muscular dystrophy.