In particular, the AML1-ETO associated M2 AML occurs in both children and adult with better prognosis (Marcucci et al., 2005; Faber et al., 2016), whereas the ETO2-GLIS2 associated M7 AML is found only in children with poor prognosis (Gruber et al., 2012; Thiollier et al., 2012; Masetti et al., 2013; de Rooij et al., 2017; Hara et al., 2017; Smith et al., 2020; Liu et al., 2022). The gene discussed is GLIS2; the disease is acute myeloid leukemia.