RUNX1 and acute myeloid leukemia: AML1-ETO is the product of t(8;21)(q22;q22), the first chromosomal translocation ever discovered (Rowley, 1973), and is mainly associated with the French-American-British (FAB) M2 subtype of acute myeloid leukemia (AML) (Licht, 2001; Peterson and Zhang, 2004).