AKT1 and neoplasm: In addition, it has been realized that TRAIL death receptors, apart from inducing apoptosis, can also activate several pro-inflammatory signal transduction pathways like Mitogen-activated protein kinases (MAPKs), nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-κB), Src kinase (Src), protein kinase C (PKC) and AKT which may enhance tumor cell malignancy (Degli-Esposti et al., 1997a; Schneider et al., 1997; Trauzold et al., 2001; Secchiero et al., 2003; Siegmund et al., 2007; Azijli et al., 2012; Azijli et al., 2013).