Overexpression studies showed that TRAIL-R4 can protect tumor cells from TRAIL-induced apoptosis by acting as a decoy receptor for ligand binding and/or inhibiting DISC formation by interacting with the TRAIL death receptors (Pan et al., 1997a; Marsters et al., 1997; Clancy et al., 2005; Merino et al., 2006; Neumann et al., 2014). This evidence concerns the gene TNFRSF10D and neoplasm.