These are two model cell lines for studying pancreatic cancer (Colo357) and breast cancer (MDA-MB-231), representing two human cancer entities with well-documented prognostic significance of the TRAIL/TRAIL-R system (Ganten et al., 2009; Haselmann et al., 2014; von Karstedt et al., 2015; Gundlach et al., 2018; Heilmann et al., 2019). Here, TNFSF10 is linked to familial pancreatic carcinoma.