CDH5 and neoplasm: Endothelial cells with diminished levels of TRPV4 exhibit reduced mechanosensitivity, which increases cell migration on stiffer substrates and decreases VE-cadherin at cell-cell junctions, leading to abnormal angiogenesis, enhanced tumor growth, and enhanced lung metastasis (Adapala et al., 2016; Cappelli et al., 2019).