TRP channels implicated in mechanotransduction mechanisms that regulate cancer cell migration, invasion and metastasis include, among others, TRPC1, TRPC5, TRPM2, TRPM7, TRPM4, TRPV2 and TRPV4 (Table 3) (Patel et al., 2010; Canales et al., 2019). This evidence concerns the gene TRPC5 and cancer.