TRPC5 and malignant colon neoplasm: TRPC5 also regulates the chemoresistance of colon cancer cells by enhancing Wnt/β-catenin signaling, which increases the expression of P-glycoprotein (Wang et al., 2015), an ABC drug efflux transporter, and glucose transporter 1 (GLUT1) (Wang et al., 2017).