BICC1 and polycystic kidney disease: Targeted mutations of mouse Bicc1 as well as morpholino disruption of Xenopus and zebrafish Bicc1 orthologs in developing embryos all result in abnormal kidneys that closely resemble defects due to polycystic kidney disease (PKD) (Cogswell et al., 2003; Tran et al., 2007, 2010; Maisonneuve et al., 2009; Bouvrette et al., 2010).