FGFR2 and cholangiocarcinoma: One of the most prevalent genome rearrangements that gives rise to cholangiocarcinomas is a fusion between the genes encoding FGFR2 (Fibroblast growth factor receptor 2) and BICC1 that results in the production of an FGFR2-Bicc1 fusion protein (Arai et al., 2014; Ross et al., 2014; Li et al., 2020; Scheiter et al., 2021).