In model organisms mutations of mouse Bicc1 as well as morpholino disruption of Xenopus and zebrafish Bicc1 orthologs in developing embryos result in cystic kidneys (Cogswell et al., 2003; Tran et al., 2007, 2010; Bouvrette et al., 2010) that closely resemble the defects due to PKD. This evidence concerns the gene BICC1 and Renal cyst.