Marked downregulation of METTL16 was observed in PDA tissues compared with adjacent nontumor tissues in both GEO datasets (p < 0.05, Figures 2A,B), whereas repression of ALKBH5 occurred only in GSE28735 (p < 0.05, Figures 2C,D). This evidence concerns the gene ALKBH5 and Patent ductus arteriosus.