Similarly, CD163+ macrophage muscle infiltration correlates with skeletal muscles atrophy in patients with pancreatic cancer and macrophage depletion leads to reduced systemic inflammation and muscle wasting in pancreatic tumor-bearing mice, indicating that both macrophage number and polarization might play a role in the progression of cancer cachexia (Shukla et al., 2020). The gene discussed is CD163; the disease is pancreatic neoplasm.