Interestingly, Spiegelman lab demonstrated that the tumor-derived parathyroid-hormone-related protein (PTHrP) induces adipose tissue browning and muscle wasting (Kir et al., 2014) and that the knocking-out of PTH-receptor only in adipose tissue results not only in impaired browning process but also in preserved muscle mass (Kir et al., 2016). Here, PTHLH is linked to neoplasm.