Beside the already mentioned ghrelin and leptin, also Glucagon-like peptide 1 (GLP-1), Lipocalin 2 (LCN2), Insulin-like 3 (INSL3), and Growth differentiation factor 15 (GDF15) can induce anorexia in cancer cachexia by directly acting on the brain centres of appetite regulation (Argilés et al., 2019a; Olson, et al., 2021b). The gene discussed is GDF15; the disease is cancer.