The CTD has been of great interest due to its intrinsic aggregation-prone property like the prion-like domain (King et al., 2012) which apparently contributes to TDP-43-induced pathological inclusions and neurotoxicity in ALS or FTLD-TDP (Afroz et al., 2017; Santamaria et al., 2017). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.