TARDBP and amyotrophic lateral sclerosis: A 414-amino acid TDP-43 protein contains an N-terminal domain with a nuclear localization signal (NLS), two RNA recognition motifs (RRM1 and RRM2) with a nuclear export signal (NES), mitochondria localization signals (M1-M5), and a glycine-rich C-terminal domain where multiple ALS-associated mutations were reported (Figure 1B) (Guerrero et al., 2016; Prasad et al., 2019).