In the first section we discussed the evidence supporting the hypothesis that cancer cells use immune chemotactic signaling to migrate toward lymph nodes and that they may also use lymphangiogenic signaling molecules such as VEGF-C to induce immunosuppression in the primary tumor (He et al., 2004; Sleeman and Thiele, 2009; Farnsworth et al., 2018). This evidence concerns the gene VEGFC and cancer.