Immature myeloid cells from the bone marrow migrate to the tumor environment in response to VEGF-A and subsequently increase lymphangiogenesis by integrating into pre-existing lymphatic vessels near the tumor and differentiating into lymphatic endothelial cells (Schoppmann et al., 2006; Zumsteg et al., 2009; Lee et al., 2010; Ding et al., 2012; Tawada et al., 2014). The gene discussed is VEGFA; the disease is neoplasm.