CDH1 and gastric cancer: This region may be important for controlling cell adhesion because several activation distinguishing antibodies bind at the EC3–4 boundary (17), many gastric cancer mutations are in the EC4–5 region of E-cadherin (11, 19), and aberrant N-linked glycosylation of Asn554 in EC4 has been linked to poorer gastric cancer outcomes and weakened adhesion (49).