In ICD, the damage-associated molecular patterns (DAMPs) molecules, including calreticulin (CRT) and heat shock proteins (HSPs), are expressed on the tumor cell surface, and high mobility group box 1 (HMGB-1) and adenosine triphosphate (ATP) are released from tumor cells, both of which improve the tumor immunogenicity [16]. Here, HMGB1 is linked to neoplasm.