Another evidence supported that METTL3 and m6A were upregulated in the liver tissues of T2D compared with non-diabetes patients, and the silence of METTL3 expression reduced m6A methylation and FASN mRNA levels, inhibited fatty acid metabolism thus improving insulin sensitivity, and prevented abnormal lipids and cholesterol metabolism (45). The gene discussed is INS; the disease is type 2 diabetes mellitus.