Overexpression of METTL3 enhanced the stability and expression of nuclear receptor-binding SET domain protein 2 (NSD2) in the high-glucose-induced mouse mesangial cell lines and that NSD2 overexpression attenuated pathological changes in the kidney, including glomerular dilatation, glomerulosclerosis, thylakoid proliferation, and interstitial fibrosis (31). This evidence concerns the gene NSD2 and glomerulosclerosis.