PPARD and Hyperglycemia: A study demonstrated that FTO not only facilitated adipogenesis and lipid droplet formation but also disordered lipid utilization in skeletal muscles through the inhibition of PPARβ/δ and AMPK pathways; the upregulation of FTO also reduced insulin secretion by the inflammatory NF-κB pathway and led to the development of hyperglycemia and hyperlipidemia (64).