For example, the overexpression of METTL14 in HRGECs markedly increased reactive oxygen species (ROS), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), apoptosis, and suppressed cell proliferation by suppressing the m6A modification of α-klotho, while α-klotho can prevent tubular and glomerular injury and delayed DN (35, 48). This evidence concerns the gene KL and liver dysplastic nodule.