FOXO1 and type 2 diabetes mellitus: A study found that hyperglycemia enhanced FTO expression in the white blood cells of T2D patients, which promoted the mRNA expression of forkhead box O1 (FOXO1), fatty acid synthetase (FASN), glucose-6-phosphatase catalytic subunit (G6PC), and diacylglycerol O-acyltransferase 2 (DGAT2); all four genes played a critical role in glucose and lipid metabolism via IR in T2D (13, 41–44).