We had also performed a post-hoc analysis on the GLP-1 levels at 0, 30, and 120 min, ΔGLP-130 min, ΔGLP1120 min and AUCGLP-1 in metformin-treated or metformin-naive T2DM patients and noted no significant differences (data not shown). This evidence concerns the gene GCG and type 2 diabetes mellitus.