Fat mass and obesity-associated protein (FTO) pro-obesity rs1421085 T-to-C single-nucleotide polymorphism (SNP) shifts differentiation programming towards white adipocytes in subcutaneous fat (4). Meanwhile in community, unhealthy lifestyles such as nutrient surplus and unhealthy eating patterns (5) act as the main reason for the high incidence of lipid metabolism disorder. Here, FTO is linked to obesity due to melanocortin 4 receptor deficiency.