NAFLD is a complex metabolic disease and many pathological changes happened in liver tissue (94).The RNA m6A methylation regulator FTO, METTL3, and the recognition protein family YTHDF affect the progression of NAFLD to hepatocellular carcinoma (HCC) by the means of disorder lipid metabolism, oxidative stress (87), and autophagy (80), making it an important potential treatment target. The gene discussed is METTL3; the disease is metabolic disease.