Conversely, METTL3 knockdown increased the free fatty acid uptake mediated by CD36, and the inflammation reaction induced by C-C motif chemokine ligand 2 (CCL2), as the result, lead to the progression from NAFLD to non-alcoholic steatohepatitis (NASH) (81). Here, METTL3 is linked to metabolic dysfunction-associated steatohepatitis.