HIF1A and neoplasm: As is known from the previous chapter, in many tumors, including glioblastoma, HIF-1α is deregulated with activation of a number of genes involved in angiogenesis (for example, VEGF), metabolic adaptation (for example, GLUT-1), cell survival (for example, the family Bcl-2) and in tumor metastasis (e.g., PDGF), stimulating tumor progression (Fig. 1).