MiRNAs are involved in most important cell biological processes such as control of cell cycle, cellular differentiation, proliferation, apoptosis, immune response, etc. Previous studies have indicated that miRNAs play a critical role in regulating oncogenesis of various human cancers through the inhibition or activation of GLUT proteins (Table 1) [[15], [16], [17], [18], [19], [20], [21], [22], [23], [24]]. The gene discussed is SLC2A1; the disease is cancer.