THBS1 had been extensively studied in renal, myocardial, and hepatic fibrotic diseases and had been found to play an important role in various ophthalmic diseases, namely, dry eye, ocular allergy, angiogenesis, lymphangiogenesis, wound healing, corneal transplantation, and infection. The gene discussed is THBS1; the disease is Keratoconjunctivitis sicca.