qRT-PCR validation of 39 pairs HCC and paracarcinoma tissues proved that SQSTM1 (P = 0.026), CSNK2B (P = 0.033), PGAM5 (P = 0.023), and ATG5 (P = 0.004) were upregulated. The gene discussed is PGAM5; the disease is hepatocellular carcinoma.