The results indicated that there were 6 overlapping genes between humans and rats; of these, 3 genes were consistent direction in both the human COPD and rat gene datasets, including AHRR/Ahrr, KCNMB2/Kcnmb2, and MRC1/Mrc1. The gene discussed is KCNMB2; the disease is chronic obstructive pulmonary disease.