Figure 5(b), B represents the combined 8 human microarray data in COPD vs. normal nonsmokers; Figures 5(b), E and 5(b), H represent the corresponding rat RNA-seq data on CS6m vs. normal nonexposed rats with the overlapping genes highlighted in red color. The common significantly overlapping genes (|log2FC|¤1 and P < 0.01) between COPD vs. normal nonsmokers and CS6m vs. normal nonexposed were AHRR/Ahrr, KCNMB2/Kcnmb2, MRC1/Mrc1, FMO2/Fmo2, ITLN1/Itln1, and C3/c3 (also shown in Figures 6(a), B and 6(b), B). The gene discussed is C3; the disease is chronic obstructive pulmonary disease.