We used the same model to establish a logistic model using AHRR/Ahrr and KCNMB2/Kcnmb2, and COPD smoker participants can be distinguished predicted with high sensitivity (0.96) and specificity (0.97), and the auROC also reached 0.98 in our dataset, compared to normal nonsmokers (Figure 7). The gene discussed is KCNMB2; the disease is chronic obstructive pulmonary disease.