Besides MPPα, biallelic mutations in the encoding gene of MPPβ, PMPCB (p.R175C/p.A201P, p.V177G/p.R175H, p.I422T, p.E396D), caused a complex and severe neurological phenotype of neurodegeneration and cerebellar atrophy in early childhood (Vögtle et al., 2018). This evidence concerns the gene PMPCB and Cerebellar atrophy.