Mice selectively overexpressing TRPV3 in K14-positive cells displayed augmented withdrawal behaviors to noxious heat only when TRPV1 was inhibited; this TRPV3-induced hyperalgesia is mediated by the production of COX-1 and PGE2 in KCs (Huang et al., 2008). The gene discussed is TRPV3; the disease is dry eye syndrome.