TRPA1 can be activated by environmental irritants, and is involved in cutaneous inflammatory diseases, including allergic dermatitis, UVB-induced injury, and atopic dermatitis; but evidence specific to KCs TRPA1 was limited (Oh et al., 2013; Kang et al., 2017; Camponogara et al., 2020). The gene discussed is TBCE; the disease is atopic eczema.