RD3 and retinal degeneration: As a result, mutations in RD3 and/or RetGC1 that disable RD3 binding are believed to cause Lebering are belie amaurosis (Azadi et al., 2010; Zulliger et al., 2015) and various forms of retinal degeneration (Friedman et al., 2006; Azadi et al., 2010; Molday et al., 2013, 2014).