Defects in WIPI2 cause a disease characterized mainly by intellectual disability and variable other features while pathogenic variants in WDR45B and WDR45 have been recently reported to cause El-Hattab-Alkuraya syndrome and beta-propeller protein-associated neurodegeneration (BPAN), respectively. The gene discussed is WDR45B; the disease is neurodevelopmental disorder with spastic quadriplegia and brain abnormalities with or without seizures.