Aring et al. generated WDR45-knockout SH-SY5Y neuroblastoma cell line using CRISPR-Cas9-mediated genome editing and they showed loss of WDR45 led to defects in ferritinophagy, a form of autophagy that degrades the iron storage protein ferritin (Aring et al., 2022). Here, WDR45 is linked to neuroblastoma.